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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

If you are taking Cialis or other medications to enhance blood pressure, it is important to follow the prescribed dosage and duration of treatment for optimal results.

C.

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness. Here are the key drug-food Interactions to be aware of:

  1. : Grapefruit can increase the levels of tadalafil by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). This increase in blood pressure can amplify side effects, such as headaches, dizziness, or low blood pressure.
  2. : Though this drug is not a direct interaction, combining alcohol with Cialis might exacerbate side effects like headaches or increase heart rate in sensitive individuals.

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Nicknamed “The Weekender Pill”,Tadalafil is the generic version of Cialis™. It lasts up to 36 hours and the reason some prefer Tadalafil over Sildenafil, which typically last up to 8 hours. Please select your preferred dosage and number of pills.

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Lilly Cialis Sales - $20.2 Billion

A year ago, Eli Lilly & Co. announced the first of its kind, a revolutionary drug for the treatment of erectile dysfunction in men. The company was the world's first company to develop the drug.

The new drug, Cialis, will be approved in the United States under the brand name Tadalafil, with a price tag of $20.2 billion. The drug's first-ever clinical trial was sponsored by Pfizer Inc. and Eli Lilly and Company, a pharmaceutical company based in Indianapolis, Ind.

The drug is an effective treatment for erectile dysfunction and works by increasing blood flow to the penis. The drug is available in 10 mg, 20 mg, and 40 mg strengths, according to Lilly.

Cialis is the most popular of the three. It is sold by Lilly in more than 150 countries and is available in 60 mg, 150 mg, and 200 mg strengths.

Lilly is a leading drug maker with a strong track record for innovation and high profit margins, with a combined annual revenue of approximately $1.5 billion.

Lilly is the world's largest drug maker by revenue, with a combined annual revenue of approximately $4.7 billion.

Copyright © 2025 KENTcollege.com. All Rights Reserved.Tadalafil and Vial of Lilly

Tadalafil and Vial of Lilly, the company's first-ever clinical trial, sponsored by Pfizer Inc., will be presented by Eli Lilly and Company at the annual meeting of the American Society of Sexual Medicine on October 30, 2025.

The trial, sponsored by Eli Lilly & Company, will provide patients with a new and improved way of treating erectile dysfunction. Patients with impotence may also be given a lower dose of the drug, such as 20 mg or 40 mg, compared to the placebo. Tadalafil is also available in 60 mg, 150 mg, and 200 mg strengths, according to Lilly.

Lilly and the drug's leading partner, Eli Lilly and Company, will be presenting at the annual meeting of the American Society of Sexual Medicine, in Chicago, on October 30, 2025.

Cialis and Vial of Lilly

The company's lead product is the treatment of benign prostatic hyperplasia, or BPH, an enlarged prostate in men with symptoms of an enlarged prostate. The most common causes of BPH are prostatic enlargement, which is a condition in which the prostate gland becomes smaller.

The drug is the first of three oral drugs for treating the condition, the most commonly used being Viagra.

The other drugs for BPH include an alpha-blocker called Proscar, which is used for the treatment of BPH, and a PDE5 inhibitor called Avonex. Viagra is also approved for the treatment of erectile dysfunction in men, but it is not effective for treating the condition. PDE5 inhibitors are a type of medicine that help to relax the blood vessels in the penis, allowing more blood to flow into it.

Tadalafil and Vial of Lilly will be presented by Eli Lilly and Company, which has over 200 U. S. pharmacies.

Tadalafil and Vial of Lilly, the company's first-ever clinical trial, sponsored by Pfizer Inc., will be presented by Eli Lilly and Company at the annual meeting of the American Society of Sexual Medicine, in Chicago, on November 14, 2025.

The trial, sponsored by Eli Lilly and Company, will provide patients with a new and improved way of treating erectile dysfunction.

Lilly and the drug's leading partner, Eli Lilly and Company, will be presented at the annual meeting of the American Society of Sexual Medicine, in Chicago, on November 14, 2025.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

C jelly (Cialis jelly) is a non-steroidal anti-inflammatory drug (NSAID) used to treat symptoms of pain and inflammation in the body. This component provides relief from pain and inflammation. Cialis is not intended to be taken by pregnant, nursing, or child-related subjects. Cialis is aUnknown drug approved for use in the United States on May 9, 2023. Oxford Health Careourcing Pvt. Ltd.https://www. OXCP.in/product/539/Cialis

6. Oxford Pharmacy.

Common cold (icariin) can be used for the treatment of cold sores. If you do experience sores, stop taking corticosteroid and contact your doctor. Cialis (tadalafil) is not intended to be taken by subjects who are hypersensitive to tadalafil or any of its ingredients.OXCP.in/product/625/icariin

7. Johnson & Johnson.https://www.vj.co.uk/product/3109/ICARI

Non-steroidal anti-inflammatory drugs (NSAIDs) like Cialis are not expected to be affected by taking this medication. There is no evidence that these drugs are affected by taking Cialis. Cambridge Science and Medical Research Group.https://www.camsu.ac.uk.

8. The NIH.https://www.nli.nih.gov.

See also below the similarities and differences between Cialis and tadalafil. 9. Oxford University Press.OXCP.in/product/977/ICIRATadalafil is an anti-ulcer drug. 10. Pune. 11. 13. Pune.........

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